Author(s): Dr Muhammad Wasim, Dermatologist (2023)
Reviewing dermatologist: Dr Ian Coulson
Edited by the DermNet content department
19-year-old female presented with:
She has a history of psoriasis, and had scaly lesions on her elbow and palms.
This is systemic lupus erythematosus (SLE) overlapping with psoriasis.
There are no randomised controlled trials for concomitant SLE and psoriasis, as limited cases are reported worldwide.
Apremilast 30 mg oral twice daily and methylprednisolone 25 mg oral once daily along with sunscreen and topical steroids were used.
She responded very well and is now in complete clinical remission.
Antimalarials were avoided as although these can be very helpful for the joint and skin manifestations of SLE, they can cause an exacerbation of psoriasis.
Interleukin (IL) 17A inhibitors may help both diseases; TNF antagonists may exacerbate SLE.
