Transient acantholytic dermatosis or Grover disease generally affects elderly men, who often present with pruritic erythematous papules, erosions and vesicles predominantly on the upper torso.
There are four histological patterns described in transient acantholytic dermatosis. More than one histological pattern may be present.
Microscopically, there is clefting in the upper layers secondary to acantholysis. There is usually a superficial dermal infiltrate of lymphocytes and eosinophils are sometimes present. Eosinophilic spongiosis is common in early lesions.
Direct immunofluroscence is negative.
